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SUMMARY OBJECTIVE: Bronchiectasis is a chronic respiratory disease characterized by inflammation, irreversible dilation of the bronchi, and recurrent pulmonary infections, with a high morbidity and mortality rate, but is less studied from the point of view of its prevalence and associated factors not directly related to respiratory prognosis. As it is a disease related to the exacerbation of the inflammatory process and oxidative stress, this study searched to investigate the micronucleus frequency in patients with and without bronchiectasis treated at a specialized pulmonology service in a hospital in the extreme south of Brazil. METHODS: Patients with a confirmed tomographic diagnosis of bronchiectasis were defined as cases. Mutagenicity was evaluated by the micronucleus test in patients' oral mucosa cells. Data collection was performed through a questionnaire containing socioeconomic, demographic, lifestyle, and health condition information. RESULTS: Of the 95 patients involved in this study, 21 (22.1%) were diagnosed with bronchiectasis aged between 12 and 89 years. There was no significant difference in the frequency of micronucleus between patients with and without bronchiectasis. There was a significant positive association between age and frequency of micronucleus among patients with bronchiectasis, but this association does not occur among patients without the disease. CONCLUSION: This is the first study to investigate data on the prevalence and clinical and epidemiological aspects of this chronic disease in Brazil, especially those related to the genotoxicity outcome.
RESUMO
Resumo O objetivo deste artigo é avaliar a prevalência e os fatores associados à dor lombar nos últimos 12 meses entre adolescentes de um município do sul do estado do Piauí, Brasil. Estudo transversal com 1112 adolescentes de 13-19 anos do município de Caracol. Investigaram-se características demográficas, socioeconômicas, nutricionais, comportamentais e comorbidades. O desfecho foi a ocorrência de dor lombar (DL) nos últimos 12 meses. Foi calculada a prevalência do desfecho de acordo com as variáveis independentes. Entre os adolescentes com DL no último ano, foi calculada a proporção de indivíduos com dor lombar crônica. Para análise dos fatores associados, foi utilizada a regressão de Poisson bruta e ajustada para cálculo das razões de prevalência. A prevalência de dor lombar nos últimos 12 meses foi de 32,9%. De acordo com a análise ajustada, sexo feminino (RP = 1,75; IC95%:1,45-2,10), idade entre 18-19 anos (RP = 1,27; IC95%:1,01-1,62), maior renda (RP = 1,33; IC95%:1,06-1,67), estar trabalhando (RP 1,25 IC95%:1,02-1,53) e apresentar distúrbios psiquiátricos menores (RP 1,51 IC95%: 1,25-1,82) permaneceram associados à DL nos últimos 12 meses. Este estudo encontrou elevada prevalência de DL entre adolescentes de um município pequeno do semiárido nordestino.
Abstract The scope of this article is to assess low back pain prevalence and associated factors in the last 12 months among adolescents in a city in the south of the State of Piauí. It was a cross-sectional study which included 1,112 adolescents aged 13-19 in the city of Caracol, Piauí. Demographic, socio-economic, nutritional, behavioral and comorbidty characteristics were investigated. The outcome was the occurrence of low back pain (LBP) in the last 12 months. The outcome prevalence was calculated in accordance with independent variables. The proportion of individuals with chronic LBP was calculated among adolescents with LBP in the last 12 months. Crude and adjusted Poisson regression was used to estimate the prevalence ratio in the analysis of associated factors. The prevalence of LBP in the last 12 months was 32.9%. According to the adjusted analysis, being female (PR = 1.75; 95%CI:1.45-2.10), being aged 18-19 (PR = 1.27; 95%CI:1.01-1.62), having higher income (PR = 1.33; 95%CI:1.06-1.67), having a job (PR 1.25 95%CI:1.02-1.53) and having minor psychiatric disorders (PR 1.51 95%CI: 1.25-1.82) were associated with LBP in the last 12 months. This study found a high prevalence of LBP among adolescents in a poor city in the semiarid region of Northeast Brazil.